Prognostic Factors Associated With Mortality Among Patients With Necrotizing Soft-Tissue Infection: A Systematic Review and Meta-Analysis
Authors' conclusion
Several patient and illness factors demonstrate important association with mortality among patients with NSTI.
Study context
- Population
- Adults with necrotizing soft-tissue infection (NSTI)
- Participants
- 168,261 adults · 41 cohort studies
- Outcome
- Short-term mortality (prognostic factors in adjusted models accounting for at least age and comorbidity)
Methodological detailsrandom-effects model, QUIPS risk-of-bias assessment, GRADE certainty of evidence, predominantly retrospective cohorts, Searched Medline, Embase and Cochrane CENTRAL from inception to September 29, 2025
- Random-effects model
- QUIPS risk-of-bias assessment
- GRADE certainty of evidence
- Predominantly retrospective cohorts
- Searched Medline, Embase and Cochrane CENTRAL from inception to September 29, 2025
Pooled result
As reported in the abstract
Prognostic factors associated with increased mortality (moderate or high certainty)
- Patient factors: older age, chronic liver disease, CKD, high Charlson Comorbidity Index, immunosuppression
- Disease factors: hypotension, bacteremia, AKI, coagulopathy, thrombocytopenia, shock
Original publication
Prognostic Factors Associated With Mortality Among Patients With Necrotizing Soft-Tissue Infection: A Systematic Review and Meta-Analysis. Crit Care Med. Published 15 May 2026. doi:10.
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