Perioperative medicine & outcomes
Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE ‐A Cohort of 1.2 Million Surgeries
Study context
- Population
- Surgical procedures performed in the Capital and Zealand Regions of Denmark, 2017 to 2025 (Danish TRIPLE-A database)
- Participants
- 1.2 million surgical procedures
- Primary endpoint
- Prognostic factors for 18 major postoperative complications in 10 domains
Methodological detailsaggregate protocol for 10 observational studies, electronic health record data, multivariable logistic regression with LASSO penalisation, Complications identified via validated combinations of ICD-10 codes, medication administration, laboratory values, radiology examinations and free-text mining of clinical notes, Effect estimates as ORs with 95% CIs; relative contribution of predictors by change in discrimination (Δ-AUC)
- Aggregate protocol for 10 observational studies
- Electronic health record data
- Multivariable logistic regression with LASSO penalisation
- Complications identified via validated combinations of ICD-10 codes, medication administration, laboratory values, radiology examinations and free-text mining of clinical notes
- Effect estimates as ORs with 95% CIs; relative contribution of predictors by change in discrimination (Δ-AUC)
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE ‐A Cohort of 1.2 Million Surgeries. Acta Anaesthesiol Scand. Published 25 June 2026. doi:10.
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