Cardiac arrest & resuscitation
Prognostic performance of plasma and urinary biomarkers of kidney injury and function after out-of-hospital cardiac arrest
Authors' conclusion
Kidney-specific biomarkers were superior to sCr for early AKI detection and prediction of patient-centered outcomes after OHCA.
Study context
- Population
- Comatose adult out-of-hospital cardiac arrest (OHCA) patients
- Participants
- 82 patients
- Exposure
- Kidney injury biomarkers vs serum creatinine for prediction
- Outcome
- Poor neurological recovery or mortality (CPC 3-5)
- Follow-up
- Hospital discharge
Main finding
As reported in the abstract
CPC 3-5
| Group | AUC |
|---|---|
| Urinary neutrophil gelatinase-associated lipocalin (NGAL) | 0.79 |
| Serum creatinine (sCr) | 0.57 |
AUC
Urinary neutrophil gelatinase-associated lipocalin (NGAL)0.79
Serum creatinine (sCr)0.57
- Cerebral Performance Category (CPC) 3-5 overall
- 45 (54.9%)
- Died (CPC 5)
- 39
- Poor neurological recovery (CPC 3-4)
- 6
Observational data: associations, not effects.
Secondary outcomes
| Outcome | sCr | P value |
|---|---|---|
| CPC 3-5 incidence by sCr trajectorysCr rose by >20% and/or required dialysis vs sCr decreasing by >20% or stable · elevated biomarkers in sCr rise >20% and/or dialysis | P < 0.001 | |
| AKI prediction, admission kidney biomarkers vs sCr | ||
| AUC | 0.65 |
- Acute kidney injury (AKI) prediction, urinary NGAL
- 0.81 · AUC
- CPC 3-5 incidence by sCr trajectory: sCr rose by >20% and/or required dialysis 71%
- CPC 3-5 incidence by sCr trajectory: sCr decreasing by >20% or stable 20%
- CPC 3-5 incidence by sCr trajectory: sCr rose by >20% n = 33; decreasing by >20% n = 23; stable n = 7
- AKI prediction, admission kidney biomarkers vs sCr: Admission kidney biomarkers AUC 0.75-0.85
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prognostic performance of plasma and urinary biomarkers of kidney injury and function after out-of-hospital cardiac arrest. Resuscitation. Published 8 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →