Cardiac arrest & resuscitation
Kidney-specific biomarkers for predicting acute kidney injury following cardiac arrest
Authors' conclusion
In post-CA patients, creatinine, NGAL, and cystatin-C (but not KIM-1) measured shortly after ROSC were higher in patients who subsequently developed AKI. No biomarker was statistically superior to creatinine on its own for predicting the development of post-arrest AKI.
Study context
- Population
- Adults after cardiac arrest with kidney biomarkers collected within 12 h of return of spontaneous circulation (ROSC)
- Participants
- 153 adults
- Comparison
- Neutrophil gelatinase-associated lipocalin (NGAL), KIM-1 and cystatin-C vs serum creatinine for predicting acute kidney injury (AKI)
- Outcome
- KDIGO stage III AKI
- Follow-up
- Within 7 days of enrollment
Performance
As reported in the abstract
Stage III AKI · within 7 days
- Stage III AKI incidence
- 54 (35%)
- Higher median creatinine, NGAL and cystatin-C in patients who developed stage III AKI
- p < 0.001 for all
- No biomarker outperformed creatinine in predicting stage III AKI
- p > 0.05 for all
- NGAL, cystatin-C and creatinine all predicted AKI better than KIM-1
- p < 0.01 for all
Further findings
Mortality before hospital discharge
- Died prior to hospital discharge
- 98 (64%)
Neurological outcomes and survival
- No biomarker outperformed creatinine in predicting neurological or survival outcomes
- P > 0.05 for all
Original publication
Kidney-specific biomarkers for predicting acute kidney injury following cardiac arrest. Resuscitation. Published 25 July 2023. doi:10.
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