Prognostic Relevance of Inflammatory Subphenotypes in Immunocompromised Patients With Sepsis
Authors' conclusion
Preexisting immune status is associated with subphenotype assignment and may influence its prognostic utility.
Study context
- Population
- ICU patients with sepsis, two US cohorts
- Participants
- 1,826 patients · 2 combined sepsis cohorts
- Exposure
- Immunocompromise type vs none, association with hyperinflammatory subphenotype
- Outcome
- Hyperinflammatory subphenotype
Methodological detailstwo cohorts, prospective data
- Two cohorts
- Prospective data
Main finding
As reported in the abstract
Odds ratio
4.3
P < 0.0001
Hematologic malignancy · persisted after adjustment for identified pathogen, bacteremia, or illness severity
Odds ratio
1.6
P = 0.02
Solid organ transplant · no longer significant after accounting for bacteremia
Observational data: associations, not effects.
Further findings
Survival by subphenotype (subgroup)
- Hyperinflammatory classification associated with decreased likelihood of survival in hematologic malignancy, but not in organ transplant or solid malignancy
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prognostic Relevance of Inflammatory Subphenotypes in Immunocompromised Patients With Sepsis. Crit Care Med. Published 28 October 2025. doi:10.
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