Prognostic value of respiratory compliance course on mortality in COVID-19 patients with veno-venous extra-corporal membrane oxygenation (vv-ECMO)
Authors' conclusion
In COVID-19-associated ARDS, static respiratory compliance course over the first ten days post-vv-ECMO implantation is associated with 180-day mortality.
Study context
- Population
- Patients with COVID-19-associated acute respiratory distress syndrome (ARDS) supported by vv-ECMO, 3 ECMO referral centres, 03/01/2020 to 12/31/2021
- Participants
- 122 patients
- Exposure
- 180-day survivors vs non-survivors
- Outcome
- Association between static respiratory compliance over first 10 days post-vv-ECMO implantation and 180-day mortality
- Follow-up
- 180 days
Methodological detailsmulticentre, Ventilated with ultra-protective settings targeting driving pressure <15 cmH2O
- Multicentre
- Ventilated with ultra-protective settings targeting driving pressure <15 cmH2O
Main finding
As reported in the abstract
Static respiratory compliance over first 10 days
Survivors
from 18 (12-25) to 20 (15-27)
mL/cmH2O
Non-survivors
from 12 (9-20) to 10 (8-14)
mL/cmH2O
P for interaction < 0.0001
Observational data: associations, not effects.
Further findings
- Six-month death
- 48%
Original publication
Prognostic value of respiratory compliance course on mortality in COVID-19 patients with vv-ECMO. Ann Intensive Care. Published 21 June 2023. doi:10.
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