Prognostic value of serial (1,3)-β-d-glucan measurements in ICU patients with invasive candidiasis
Authors' conclusion
A decrease in serum BDG was associated with reduced mortality and a steep downslope predicted survival with high specificity in invasive candidiasis.
Study context
- Population
- ICU patients with proven invasive candidiasis and at least 2 BDG determinations, Italy, 2012–2022
- Participants
- 103 patients
- Exposure
- BDG downslope vs no BDG downslope
- BDG downslopen = 54
- N-BDG downslopen = 49reference
- Outcome
- Invasive candidiasis related mortality
Main finding
As reported in the abstract
P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Predictors of invasive candidiasis mortality (multivariate Cox regression)BDG downslope vs N-BDG downslope · only predictor of survival | 0.19 (0.09–0.43) | P < 0.01 | |
| 0.050.21520Hazard ratio (log scale) |
Predictors of invasive candidiasis mortality (multivariate Cox regression)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Septic shock at infection occurrence | 3.24 (1.25–8.44) | P = 0.02 | |
| Chronic liver disease | 7.27 (2.33–22.66) | P < 0.01 | |
| 0.050.21520Hazard ratio (log scale) |
- BDG downslope as predictor of good clinical outcome
- 0.74 (p = 0.02) · AUC · Specificity (downslope > 70%) 100% · PPV (downslope > 70%) 100%
Candida species
- C. albicans
- 61%
- C. parapsilosis
- 17%
- C. glabrata
- 12%
- No inter-group difference
Original publication
Prognostic value of serial (1,3)-β-d-glucan measurements in ICU patients with invasive candidiasis. Crit Care. Published 12 July 2024. doi:10.
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