Prolonged duration of action of suxamethonium in pregnant and postpartum patients: A registry study
Authors' conclusion
Among pregnant and postpartum patients with a history of prolonged duration of action of suxamethonium and a low BChE activity, 6% did not have a mutation in the BChE gene.
Study context
- Population
- Pregnant and postpartum patients with a history of prolonged duration of action of suxamethonium referred to the Danish Cholinesterase Research Unit (DCRU), March 2007–January 2023
- Participants
- 40 participants
- Outcome
- Proportion of patients without a BChE gene mutation among patients with a low BChE activity
Main finding
As reported in the abstract
No BChE gene mutation among patients with low BChE activity
Proportion without a mutation among patients with low butyrylcholinesterase (BChE) activity
6%
95% CI 1%–21%
Observational data: associations, not effects.
Secondary outcomes
Mutation in the BChE gene, all included patients
- Proportion with a mutation
- 90% (95% CI: 76%-97%)
Low BChE activity, all included patients
- Proportion with a low BChE activity
- 94% (95% CI: 80%-99%)
Original publication
Prolonged duration of action of suxamethonium in pregnant and postpartum patients: A registry study. Acta Anaesthesiol Scand. Published 24 March 2024. doi:10.
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