Prolonged Opioid Use and Pain Outcome and Associated Factors after Surgery under General Anesthesia: A Prospective Cohort Association Multicenter Study
Authors' conclusion
Preoperative opioid use was the strongest predictor of opioid use 3 months postsurgery. None of the other variables showed clinically significant association with opioid use at 3 months after surgery.
Study context
- Population
- Patients scheduled for spine, open thoracic, knee, hip or abdominal surgery, or mastectomy, under GA at 11 US and 1 European institution680 (64%) analysed
- Participants
- 1,093 patients
- Exposure
- Patient characteristics, surgical procedure and perioperative anaesthetic course as predictors of 3-month opioid use and pain
- Preoperative opioid usen = 135
- Outcome
- Postoperative opioid consumption and surgical site pain
- Follow-up
- 3 months
Methodological detailsmulticentre, observational, Intraoperative data from the Multicenter Perioperative Outcomes Group database; outcomes by telephone survey at 3 months
- Multicentre
- Observational
- Intraoperative data from the Multicenter Perioperative Outcomes Group database; outcomes by telephone survey at 3 months
Main finding
As reported in the abstract
Predictors of 3-month opioid use and surgical site pain · 3 months postsurgery
Estimate (CrI)
Opioids taken preoperativelycredible interval
adjusted OR (3-month opioid use) 18.6(10.3–34.5)
Site pain preoperatively
adjusted OR (3-month surgical site pain) 2.58(1.45–4.4)
Knee replacement
adjusted OR (3-month surgical site pain) 4.1(1.73–8.9)
Spine surgery
adjusted OR (3-month surgical site pain) 2.75(1.39–5.0)
- Taking opioids at 3 months
- 96 (14%)
- Surgical site pain at 3 months
- 177 patients (27%)
Observational data: associations, not effects.
Original publication
Prolonged Opioid Use and Pain Outcome and Associated Factors after Surgery under General Anesthesia: A Prospective Cohort Association Multicenter Study. Anesthesiology. Published 24 January 2023. doi:10.
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