Receipt of Extended-Release Opioids After Total Hip or Knee Arthroplasty and Subsequent Persistent Postoperative Opioid Use and Health System Utilization: A Population-Based Comparative Effectiveness Analysis
Main finding · PPOUResult — go to the resultAdjusted odds ratio 1.08 95% CI 1.01–1.15Authors' conclusion
Filling a new ERO prescription was associated with small but consistent increases in adverse clinical outcomes balanced against decreased 1 year health system costs.
Study context
- Population
- Adults in Ontario, Canada, undergoing elective primary total hip or knee arthroplasty, 2013–2022
- Participants
- 258,624 adults
- Exposure
- Filling a new postoperative ERO prescription vs no ERO
- EROn = 31,224
- Outcome
- Persistent postoperative opioid use (PPOU), defined by a measure accounting for preoperative opioid exposure (O-NET)
Methodological detailspropensity score overlap weighting, linked administrative datasets
- Propensity score overlap weighting
- Linked administrative datasets
Main finding
PPOU
Adjusted odds ratio
1.08
95% CI 1.01–1.15
Events by group
ERO vs Without ERO
aOR 1.08 (95% CI 1.01–1.15)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| 90-day readmissions · propensity score overlap weighting | 1.09 (1.02–1.17) | |
| 90-day ED visits · propensity score overlap weighting | 1.16 (1.12–1.21) | |
| 0.512Adjusted odds ratio (log scale) |
Total health system costs · 365 days
- Total health system costs lower with ERO filling, ratio of means (RoM), 95%CI 0.85-0.89
- 0.87
- Propensity score overlap weighting
DAH · 365 days
- DAH higher with ERO filling, ratio of means (RoM), 95%CI 1.0004-1.003
- 1.002
- Propensity score overlap weighting
Original publication
Receipt of Extended-Release Opioids After Total Hip or Knee Arthroplasty and Subsequent Persistent Postoperative Opioid Use and Health System Utilization: A Population-Based Comparative Effectiveness Analysis. Anesthesiology. Published 29 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →