Association of peri‐operative prescription of non‐steroidal anti‐inflammatory drugs with continued prescription of opioids after total knee arthroplasty: a retrospective claims‐based cohort study
Main findingResult — go to the resultAdjusted odds ratio 1.32 95% CI 1.30–1.35Authors' conclusion
This population-based cohort study suggests that peri-operative prescription NSAID use may be associated with continued opioid prescription claims at 90 and 180 days after knee arthroplasty, even after adjusting for other observed covariates for continuous opioid claims.
Study context
- Population
- Opioid-naïve adults undergoing primary knee arthroplasty, US health claims database, January 2010–October 2021
- Participants
- 789,736 adults
- Exposure
- Peri-operative prescription NSAID vs no NSAID prescription
- Outcome
- Continuous opioid claims
- Follow-up
- 90 days postoperatively
Methodological detailsclaims-based, population-based, multivariable logistic regression
- Claims-based
- Population-based
- Multivariable logistic regression
Main finding
As reported in the abstract
90 days
Adjusted odds ratio
1.32
95% CI 1.30–1.35
P < 0.001
NSAID vs No NSAID
aOR 1.32 (95% CI 1.30–1.35); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Continuous opioid claims · 180 days | 1.12 (1.10–1.15) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
Other pain medications (e.g. paracetamol)
- No such association detected
Original publication
Association of peri‐operative prescription of non‐steroidal anti‐inflammatory drugs with continued prescription of opioids after total knee arthroplasty: a retrospective claims‐based cohort study. Anaesthesia. Published 22 February 2024. doi:10.
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