Association of preoperative corticosteroids with persistent opioid requirements following total knee arthroplasty: an exploratory population-based cohort study
Main finding · Opioid claimsResult — go to the resultOdds ratio 1.34 95% CI 1.30–1.38Authors' conclusion
Our exploratory retrospective cohort study suggests that, after accounting for other potential covariates, patients who were previously opioid-naïve and who were exposed to preoperative corticosteroids may have greater odds (or risk given the low incidence) of persistent opioid claims at 3 and 6 months after TKA.
Study context
- Population
- Opioid-naïve patients undergoing primary total knee arthroplasty (TKA), nationwide US claims database, January 2010–October 2022matched cohort
- Participants
- 763,530 patients
- Exposure
- Preoperative corticosteroid claims vs none within 30 days of TKA
- Corticosteroidn = 27,510
- No corticosteroidn = 736,020reference
- Outcome
- Postoperative opioid prescription claims
- Follow-up
- 3 months
Methodological detailsexploratory, population-based, matched cohort, multivariable logistic regression
- Exploratory
- Population-based
- Matched cohort
- Multivariable logistic regression
Main finding
Opioid claims
Odds ratio
1.34
95% CI 1.30–1.38
P < 0.001
Events by group
Corticosteroid vs No corticosteroid
OR 1.34 (95% CI 1.30–1.38); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Corticosteroid | No corticosteroid | OR (97.5% CI) | P value | |
|---|---|---|---|---|---|
| Opioid claims · 6 months | 8.8% | 6.8% | 1.20 (1.15–1.25) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Original publication
Association of preoperative corticosteroids with persistent opioid requirements following total knee arthroplasty: an exploratory population-based cohort study. Can J Anaesth. Published 5 May 2026. doi:10.
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