ICU sedation, delirium & recovery
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical intensive care unit (ICU) patients: a retrospective cohort study
Main finding · MortalityResult — go to the resultAdjusted hazard ratio 1.261 95% CI 1.07–1.486Authors' conclusion
Our study demonstrated that prolonged use of NMBAs was associated with an increased risk of long-term mortality in critically ill patients requiring mechanical ventilation.
Study context
- Population
- Mechanically ventilated critically ill patients, Taichung Veterans General Hospital critical care databases, Taiwan, 2015–201963.8% male
- Participants
- 5,709 participants
- Exposure
- NMBA use for longer than 48 h vs not
- Outcome
- Mortality
- Follow-up
- One year
Methodological detailssingle-centre, national death registry linkage
- Single-centre
- National death registry linkage
Main finding
As reported in the abstract
Adjusted hazard ratio
1.261
95% CI 1.07–1.486
NMBAs >48 h vs No prolonged NMBAs
aHR 1.261 (95% CI 1.07–1.486)
Observational data: associations, not effects.
Further findings
NMBAs >48 h, non-survivors vs survivors
P < 0.001
Duration of ventilator use, non-survivors vs survivors
P < 0.001
One-year mortality, whole cohort
- One-year mortality
- 48.3% (2755/5709)
Effect modification by Charlson Comorbidity Index (subgroup)
- Association tended to be strong with Charlson Comorbidity Index of 3 or higher
Original publication
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study. J Intensive Care. Published 17 November 2023. doi:10.
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