Neuroanesthesia & neurocritical care
Prompt closure versus gradual weaning of external ventricular drainage for hydrocephalus following aneurysmal subarachnoid haemorrhage: Protocol for the DRAIN randomised clinical trial
Study context
- Population
- Patients with aneurysmal subarachnoid haemorrhage (aSAH) and hydrocephalus treated with external ventricular drain (EVD)122 planned per group
- Planned comparison
- Gradual weaning vs prompt closure of EVD
- Primary endpoint
- Composite of:
- VP-shunt implantation
- All-cause mortality
- Ventriculostomy-related infection
- Follow-up
- 6 months after ictus
Methodological detailsinternational, multi-centre, parallel group, blinded outcome assessment, Sample size: event proportion 80% in gradual weaning group, relative risk reduction 20%, type I error 5%, power 80%; 122 patients per group
- International
- Multi-centre
- Parallel group
- Blinded outcome assessment
- Sample size: event proportion 80% in gradual weaning group, relative risk reduction 20%, type I error 5%, power 80%; 122 patients per group
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Prompt closure versus gradual weaning of external ventricular drainage for hydrocephalus following aneurysmal subarachnoid haemorrhage: Protocol for the DRAIN randomised clinical trial. Acta Anaesthesiol Scand. Published 10 May 2023. doi:10.
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