Neuroanesthesia & neurocritical care
Prophylactic Antibiotics in Adults With Acute Brain Injury Who Are Invasively Ventilated in the ICU: A Systematic Review and Meta-Analysis
Pooled result · Hospital mortalityResult — go to the resultRelative risk 0.91 95% CI 0.70–1.17Authors' conclusion
Current evidence from randomized clinical trials does not provide definitive evidence regarding the effect of prophylactic antibiotics on mortality in patients receiving invasive mechanical ventilation in the ICU.
Study context
- Population
- Adults with acute brain injury receiving invasive mechanical ventilation in an ICU
- Participants
- 835 adults · 7 RCTs
- Comparison
- Prophylactic parenteral antibiotics vs placebo or usual care
- Outcome
- Hospital mortality
Methodological detailsrandom effects model, GRADE certainty assessment, No trials adjudicated as high risk of bias
- Random effects model
- GRADE certainty assessment
- No trials adjudicated as high risk of bias
Pooled result
As reported in the abstract
Relative risk
0.91
95% CI 0.70–1.17
P = 0.39
Prophylactic antibiotics vs Control
RR 0.91 (95% CI 0.70–1.17); P = 0.39
Further pooled results
| Outcome | MD (days) (95% CI) | |
|---|---|---|
| Duration of mechanical ventilationVery low certainty; similar | −2.0 (−6.1 to 2.1) | |
| ICU LOSVery low certainty; similar | −2.2 (−5.4 to 1.1) | |
| −10−505Difference, days (linear scale) |
VAP incidence
- Pooled estimated RR for VAP
- 0.56 (95% CI, 0.35-0.89)
- Low certainty
Original publication
Prophylactic Antibiotics in Adults With Acute Brain Injury Who Are Invasively Ventilated in the ICU: A Systematic Review and Meta-Analysis. Chest. Published 28 October 2024. doi:10.
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