Perioperative medicine & outcomes
Prophylactic intravenous tranexamic acid and thromboembolism in non‐cardiac surgery: a systematic review, meta‐analysis and trial sequential analysis
Authors' conclusion
It was encouraging to see the evidence that the administration of intravenous tranexamic in patients undergoing non-cardiac surgery was not associated with an increased risk of thromboembolic outcomes.
Study context
- Population
- Patients undergoing non-cardiac surgery
- Participants
- 40,621 patients · 191 RCTs
- Comparison
- IV TXA vs placebo or no treatment
- Outcome
- Composite of peri-operative cardiovascular thromboembolic events (any DVT, PE, myocardial ischaemia/infarction or cerebral ischaemia/infarction)
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Composite peri-operative cardiovascular thromboembolic events
Further pooled results
| Outcome | Tranexamic acid | Control | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Blood transfusion rate | 9.9% | 19.4% | 0.46 (0.41–0.51) | P < 0.0001 | |
| 0.512Relative risk (log scale) |
Seizure rate and mortality within 30 days
- No association between IV TXA and seizure rate or 30-day mortality
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prophylactic intravenous tranexamic acid and thromboembolism in non‐cardiac surgery: a systematic review, meta‐analysis and trial sequential analysis. Anaesthesia. Published 14 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →