Prophylactic phenylephrine and norepinephrine infusions during caesarean delivery for non-reassuring fetal heart rate: A randomised noninferiority trial to assess neonatal outcome
Primary resultResult — go to the resultMean difference 1.10 mmol l −1 95% CI 0.084–2.123Authors' conclusion
Prophylactic norepinephrine infusion (6 μg min -1 ) was found to be noninferior to phenylephrine infusion (80 μg min -1 ) in terms of umbilical arterial base excess values. A similar incidence of fetal acidosis was observed in both groups.
Study context
- Population
- Parturients with non-reassuring fetal heart rate undergoing nonelective caesarean delivery under spinal anaesthesia, tertiary care hospital, Northern Indiaanalysed
- Participants
- 104 participants
- Comparison
- Norepinephrine vs Phenylephrine
- Primary endpoint
- Umbilical arterial base excess (non-inferiority margin −0.05 mmol l −1)
Methodological detailsprospective, double-blind, non-inferiority
- Prospective
- Double-blind
- Non-inferiority
Primary result
As reported in the abstract
Mean difference
1.10 mmol l −1
95% CI 0.084–2.123
P = 0.034
By group
Norepinephrine
−6.85
mean · SD 2.20 · mmol l −1
Phenylephrine
−7.95
mean · SD 2.99 · mmol l −1
Norepinephrine vs Phenylephrine
mean difference 1.10 mmol l −1 (95% CI 0.084–2.123); P = 0.034
Further findings
Fetal acidosis · no significant difference
P = 0.140
Original publication
Prophylactic phenylephrine and norepinephrine infusions during caesarean delivery for non-reassuring fetal heart rate: A randomised noninferiority trial to assess neonatal outcome. Eur J Anaesthesiol. Published 22 August 2025. doi:10.
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