Prophylatic use of IV nalmefene to prevent epidural opioid-induced pruritus: A multicenter, randomized clinical trial
Primary resultResult — go to the resultOdds ratio 0.58 95% CI 0.35–0.96Authors' conclusion
A single dose of 0.5 μg/kg nalmefene intravenously significantly reduced the incidence and severity of epidural-opioid induced pruritus within 24 h after surgery without affecting the efficacy of epidural analgesia.
Study context
- Population
- Patients aged 18–80 years undergoing elective surgery with intra- and postoperative epidural analgesia, two tertiary hospitals in China296 analysed
- Participants
- 302 patients
- Comparison
- Prophylactic IV nalmefene 0.5 μg/kg vs saline
- Nalmefenen = 149
- Controln = 147reference
- Primary endpoint
- Incidence of pruritus
- Follow-up
- Within 24 h after surgery
Methodological detailsdouble-blinded, two-center, March 2022 to February 2023
- Double-blinded
- Two-center
- March 2022 to February 2023
Primary result
As reported in the abstract
Odds ratio
0.58
95% CI 0.35–0.96
P = 0.034
Events by treatment group
Nalmefene vs Control
OR 0.58 (95% CI 0.35–0.96); P = 0.034
Secondary outcomes
Onset and severity of pruritus · within 24 h after surgery
- Delayed onset and reduced severity of pruritus in the nalmefene group
Postoperative analgesia
- No significant difference
Safety
Vomiting · within 24 h after surgery
- Decreased in the nalmefene group
Other anesthesia/analgesia-related side effects
- No significant differences
Original publication
Prophylatic use of IV nalmefene to prevent epidural opioid-induced pruritus: A multicenter, randomized clinical trial. J Clin Anesth. Published 19 October 2023. doi:10.
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