Perioperative medicine & outcomes
Prospective Assessment of Clinically Relevant Fluid Balance Thresholds Associated With Postoperative Complications in Advanced Ovarian Cancer
Authors' conclusion
An optimal target for perioperative fluid balance to decrease the odds of major postoperative complications is suggested to be < 1750 mL. If initial ascites is included as loss in the calculation of balance, the optimal target of fluid balance is suggested to be < 2700 mL.
Study context
- Population
- Adults (> 18 years) with advanced ovarian cancer scheduled for upfront cytoreductive surgery, ASA I–III, Sweden, 2020–2023162 analysed
- Participants
- 175 adults
- Exposure
- Perioperative fluid balance categories
- Outcome
- Major postoperative complication
- Follow-up
- Within 30 days of surgery
Methodological detailsmultivariable regression adjusted for predefined covariates, a priori defined cut-offs
- Multivariable regression adjusted for predefined covariates
- A priori defined cut-offs
Main finding
As reported in the abstract
Each group vs < 1750 mLOdds ratio (95% CI)P value
1750-2700 mL
3.40(1.06–10.9)
P = 0.04> 2700 mL
3.91(1.33–11.5)
P = 0.01Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Major postoperative complications, initial ascites included as fluid loss> 2700 mL vs < 1750 mL | 2.59 (1.01–6.66) | P = 0.047 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Prospective Assessment of Clinically Relevant Fluid Balance Thresholds Associated With Postoperative Complications in Advanced Ovarian Cancer. Acta Anaesthesiol Scand. Published 26 August 2025. doi:10.
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