ICU sedation, delirium & recovery
Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study
Authors' conclusion
Almost one-third of the family members of ICU survivors reported persistent psychological symptoms and QoL problems at 12-months.
Study context
- Population
- Adult family members of ICU survivors and family-survivor dyads, four medical-surgical ICUs in Australia110/132 eligible completed ≥ 1 follow-up
- Participants
- 144 members
- Exposure
- Intubated vs Non-intubated
- Outcome
- Clinically significant psychological symptoms (PTSD/depression/anxiety) and QoL (Impact of Event Scale-Revised; Depression, Anxiety Stress Scales-21; EQ-5D-5L)
- Follow-up
- 3 and 12 months after ICU discharge
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Clinically significant psychological symptoms (PTSD/depression/anxiety) · 3 and 12 months
- Intubated vs Non-intubated: P = 0.15
- Intubated vs Non-intubated: P = 0.23
Observational data: associations, not effects.
Further findings
Clinically significant psychological symptoms (PTSD/depression/anxiety) · 3 months
P = 0.15
| Outcome | Estimate | P value | |
|---|---|---|---|
| Dyad effect: family member has the symptom/QoL problem when the paired survivor reported the samePaired survivor with symptom vs Paired survivor without symptom | OR of persistent PTSD symptoms in family member 4.9 (95% CI 1.47–16.1) | P = 0.01 | |
| Dyad effect: family member has the symptom/QoL problem when the paired survivor reported the samePaired survivor with symptom vs Paired survivor without symptom | OR of persistent depression symptoms in family member 14.6 (95% CI 2.9–72.6) | P = 0.001 | |
| Dyad effect: family member has the symptom/QoL problem when the paired survivor reported the samePaired survivor with problem vs Paired survivor without problem | OR of pain/discomfort QoL domain problems in family member 6.5 (95% CI 1.14–36.8) | P = 0.03 | |
| Dyad effect: family member has the symptom/QoL problem when the paired survivor reported the samePaired survivor with problem vs Paired survivor without problem | OR of anxiety/depression QoL domain problems in family member 3.5 (95% CI 1.02–12.1) | P = 0.04 | |
| 0.050.21520Ratio (log scale) |
Family self-rated Quality of Life (QoL) (visual analogue scale, range 0-100) · 12 months
- Problems in pain/discomfort or anxiety/depression domains
- > 30%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Psychological symptoms, quality of life and dyadic relations in family members of intensive care survivors: a multicentre, prospective longitudinal cohort study. Ann Intensive Care. Published 20 January 2025. doi:10.
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