Pediatric anesthesia & critical care
Pulmonary Atelectasis After Sedation With Propofol vs Propofol-Ketamine for Magnetic Resonance Imaging in Children: A Randomized Clinical Trial
Primary resultResult — go to the resultRelative risk 0.7 95% CI 0.5–0.8Authors' conclusion
In this randomized clinical trial, the propofol-ketamine combination reduced sedation-induced atelectasis while allowing for faster emergence compared with propofol alone.
Study context
- Population
- Children aged 3 to 12 years, ASA I to II, undergoing elective magnetic resonance imaging (MRI) under deep sedationanalysed
- Participants
- 107 children
- Comparison
- Propofol-ketamine vs propofol sedation for MRI
- Propofoln = 54reference
- Propofol-ketaminen = 53
- Primary endpoint
- Incidence of atelectasis assessed by lung ultrasonography
Methodological detailsdouble-masked, single-centre (tertiary referral center)
- Double-masked
- Single-centre (tertiary referral center)
Primary result
As reported in the abstract
Relative risk
0.7
95% CI 0.5–0.8
P < 0.001
Events by treatment group
Propofol-ketamine vs Propofol
RR 0.7 (95% CI 0.5–0.8); P < 0.001
Further findings
Median, minutes
| Outcome | Propofol | Propofol-ketamine | Median difference (minutes) (95% CI) | P value | |
|---|---|---|---|---|---|
| Emergence timeFaster emergence with propofol-ketamine | 25 (IQR 22–27) | 15 (IQR 9–23) | 9.0 (6.0–12.0) | P < 0.001 | |
| −5051015Difference, minutes (linear scale) |
MRI interruption due to airway intervention or spontaneous movement
- Did not significantly differ between the groups
Safety
Desaturation
- Did not significantly differ between the groups
Withdrawal due to adverse effects
- No patient withdrawn due to adverse effects
Original publication
Pulmonary Atelectasis After Sedation With Propofol vs Propofol-Ketamine for Magnetic Resonance Imaging in Children: A Randomized Clinical Trial. JAMA Netw Open. Published 1 November 2024. doi:10.
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