Respiratory failure & ventilation
Pulse Pressure Variation During Passive Leg Raising to Assess Preload Responsiveness: Influence of Inspiratory Effort During Pressure Support Ventilation
Authors' conclusion
During PSV, PLR-induced changes in PPV assess preload responsiveness, primarily in patients with lower inspiratory effort reflected by P 0.1 .
Study context
- Population
- Critically ill patients receiving pressure support ventilation (PSV) and requiring assessment of preload responsiveness, two French university hospital ICUs14 (41%) preload responders
- Participants
- 34 patients
- Comparison
- Passive leg raising (PLR)-induced change in PPV vs baseline PPV and PLR-induced change in pulse pressure (PP) to assess preload responsiveness
- Outcome
- Assessment of preload responsiveness
Methodological detailsprospective, two-centre
- Prospective
- Two-centre
Performance
As reported in the abstract
| Test or model | AUC | P | Cutoff |
|---|---|---|---|
| PLR-induced change in PPV | 0.76 | p = 0.026 | −3% |
PLR-induced change in PPV
AUC0.76
Pp = 0.026
Cutoff−3%
Further findings
| Outcome | Lower inspiratory effort (P 0.1 < 2.3 cm H 2 O) | Higher inspiratory effort |
|---|---|---|
| PLR-induced change in PPV by inspiratory effort (subgroup by median P 0.1) | ||
| AUC | 0.90 | 0.61 |
| P | p = 0.050 | p = 0.480 |
| Cutoff | −3% | — not stated in the abstract |
— not stated in the abstract
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pulse Pressure Variation During Passive Leg Raising to Assess Preload Responsiveness: Influence of Inspiratory Effort During Pressure Support Ventilation. Crit Care Med. Published 10 June 2026. doi:10.
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