Cardiac arrest & resuscitation
Quantitative assessment of blood–brain barrier permeability using biotechnological imaging analysis in contrast-enhanced magnetic resonance imaging during post-resuscitation care: Stratified associations by illness severity
Main finding · Agreement between ΔCon and Qa (total cohort)Result — go to the resultMean difference 0.34 95 % limits of agreement CI 0.11–0.57Authors' conclusion
This study demonstrated no significant relationship between non-invasive ΔCon derived from CE-MRI and invasive Qa when illness severity remained unstratified. After stratifying by illness severity, a subtle association between ΔCon and Qa emerged, specifically in patients with moderate severity of cardiac arrest.
Study context
- Population
- Patients receiving post-resuscitation care after OHCA who underwent contrast-enhanced magnetic resonance image (CE-MRI)
- Exposure
- ΔCon on CE-MRI vs cerebrospinal fluid (CSF)/serum albumin quotient
- Outcome
- Agreement between ΔCon and Qa (total cohort)
Main finding
As reported in the abstract
Mean difference
0.34
95 % limits of agreement CI 0.11–0.57
Observational data: associations, not effects.
Further findings
| Outcome | β | P value |
|---|---|---|
| Association of ΔCon with Qa, by PCAC illness severity (subgroup)PCAC 3 (moderate); pseudo-R2 = 0.35 | 2.94 | P = 0.03 |
Association of ΔCon with Qa, by Pittsburgh Cardiac Arrest Category (PCAC) illness severity (subgroup)
- PCAC 2 and PCAC 4: non-significant associations
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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