Cardiac arrest & resuscitation
Quantitative pupillometry index to prognosticate neurological outcome in unconscious cardiac arrest patients
Authors' conclusion
Abnormal QPI had comparable specificity and a higher sensitivity than NPi in predicting UO at 3 months in comatose patients after CA.
Study context
- Population
- Unconscious (GCS <9) patients admitted to the ICU after successful resuscitation from cardiac arrest, March 2022–October 2024193 screened
- Participants
- 111 participants
- Exposure
- Quantitative Pupillometry Index (QPI) vs Neurological Pupil Index (NPi) for prognosis of unfavourable neurological outcome
- Outcome
- Unfavourable neurological outcome (Glasgow-Pittsburgh Cerebral Performance Category 3-5)
- Follow-up
- 3 months
Methodological detailstwo-centre (Belgium and Spain), NPi and QPI measured twice at 24, 48 and 72 h after cardiac arrest (CA)
- Two-centre (Belgium and Spain)
- NPi and QPI measured twice at 24, 48 and 72 h after CA
Main finding
As reported in the abstract
Prediction of unfavourable neurological outcome · 72 h
| Group | Sensitivity | Specificity |
|---|---|---|
| QPI | 60.4 [46.0-73.5]% | 100 [87.2-100]% |
| NPi | 24.5 [13.8-38.3]% | 100 [86.8-100]% |
Sensitivity
QPI60.4 [46.0-73.5]%
NPi24.5 [13.8-38.3]%
Specificity
QPI100 [87.2-100]%
NPi100 [86.8-100]%
Observational data: associations, not effects.
Further findings
- ICU mortality
- 69 (62.2%)
- Unfavourable neurological outcome
- 79 (71%)
- Patients with UO showed lower NPi and QPI during the first three days
Original publication
Quantitative pupillometry index to prognosticate neurological outcome in unconscious cardiac arrest patients. Resuscitation. Published 20 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →