ICU sedation, delirium & recovery
Randomized Clinical Trial of the Four Supports Intervention for Surrogate Decision-Makers in Intensive Care Units
Primary resultResult — go to the resultβ 0.06 95% CI −0.07 to 0.19Authors' conclusion
Among critically ill patients at high risk of death or functional impairment, a family support intervention delivered by an external interventionist did not reduce surrogates' long-term psychological symptom burden.
Study context
- Population
- Surrogate decision-makers for incapacitated, critically ill patients at high risk of death or severe long-term functional impairment, six ICUs in Pennsylvaniasurrogates of 291 patients
- Participants
- 444 participants
- Comparison
- Intervention vs Control
- Interventionn = 233
- Controln = 211reference
- Primary endpoint
- Surrogates' Hospital Anxiety and Depression Scale score (range 0-42)
- Follow-up
- 6 months
Methodological detailspatient-level randomised, multicentre (six ICUs), Intervention delivered with high fidelity: per protocol delivery of key elements 97.1%; quality rating 2.9 ± 0.2 (scale 1 to 3)
- Patient-level randomised
- Multicentre (six ICUs)
- Intervention delivered with high fidelity: per protocol delivery of key elements 97.1%; quality rating 2.9 ± 0.2 (scale 1 to 3)
Primary result
As reported in the abstract
β
0.06
95% CI −0.07 to 0.19
P = 0.35
Secondary outcomes
- No intervention effect on the prespecified secondary outcomes
Original publication
Randomized Clinical Trial of the Four Supports Intervention for Surrogate Decision-Makers in Intensive Care Units. Am J Respir Crit Care Med. Published 1 March 2025. doi:10.
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