A Randomized Controlled Trial of Intraoperative Ketamine for Acute Postsurgical Pain after Breast Cancer Surgery: The Moderating Effect of Baseline Temporal Summation of Pain
Authors' conclusion
Ketamine was not associated with an analgesic benefit over placebo in the acute postoperative period, as measured using a variety of pain assessments.
Study context
- Population
- Patients undergoing breast cancer surgery (lumpectomy 53%, mastectomy 16%, mastectomy with reconstruction 30%)
- Participants
- 225 patients
- Comparison
- Intraoperative ketamine vs saline
- Ketaminen = 113
- Placebon = 112reference
- Primary endpoint
- Postoperative pain severity and impact
- Follow-up
- 2 weeks after surgery
Methodological detailsprospective, longitudinal, exploratory moderation analysis
- Prospective
- Longitudinal
- Exploratory moderation analysis
Primary result
As reported in the abstract
Pain severity and impact
- No significant treatment group differences in pain severity or impact
Further findings
- Among patients with higher baseline temporal summation of pain, ketamine associated with lower pain severity and impact scores
- Exploratory moderation analysis
Original publication
A Randomized Controlled Trial of Intraoperative Ketamine for Acute Postsurgical Pain after Breast Cancer Surgery: The Moderating Effect of Baseline Temporal Summation of Pain. Anesthesiology. Published 14 July 2025. doi:10.
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