A Single Preoperative Dose of S-Ketamine Has No Beneficial Effect on Chronic Postsurgical Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgical Lung Lesion Resection: A Prospective Randomized Controlled Study
Authors' conclusion
A single preoperative dose of S-ketamine in patients who underwent VATS had no significant effect on acute and chronic postoperative pain or the consumption of analgesics after surgery. A single preoperative dose of S-ketamine could improve sleep on the first day after surgery, whereas it had no significant effect on anxiety levels.
Study context
- Population
- Patients aged 18-to-65 years undergoing video-assisted thoracoscopic surgical lung lesion resection (VATS)
- Comparison
- Single preoperative dose of S-ketamine vs placebo
- Primary endpoint
- Incidence of chronic postsurgical pain (CPSP) and its neuropathic component
Methodological detailsprospective, double-blind, single-centre, Enrolled March 17, 2021, to November 18, 2021, at a single tertiary academic hospital
- Prospective
- Double-blind
- Single-centre
- Enrolled March 17, 2021, to November 18, 2021, at a single tertiary academic hospital
Primary result
As reported in the abstract
Incidence of CPSP and neuropathic pain
- No significant differences between the 2 groups in the incidences of chronic postsurgical pain (CPSP) and neuropathic pain
Secondary outcomes
Acute postoperative pain and postoperative use of analgesics
- No significant differences between the 2 groups
Sleep quality scores · first postoperative day
- Differed significantly between the groups (47.45 ± 27.58 v . 52.97 ± 27.57; group order not stated)
- P = 0.049
Anxiety scores
- No significant difference between the groups
Safety
Adverse effects
- Similar between the 2 groups
Original publication
A Single Preoperative Dose of S-Ketamine Has No Beneficial Effect on Chronic Postsurgical Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgical Lung Lesion Resection: A Prospective Randomized Controlled Study. J Cardiothorac Vasc Anesth. Published 7 March 2023. doi:10.
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