Randomized Controlled Trials in ICU in the Four Highest-Impact General Medicine Journals
Authors' conclusion
In comparison with concurrently published RCTs in non-ICU disciplines, statistical significance was rare and often hinged on the outcome events of just a few patients.
Study context
- Population
- Original Randomized Controlled Trials (RCTs) published January 2014–October 2021 in NEJM, The Lancet, JAMA and BMJ
- Participants
- 2,431 original RCTs
- Comparison
- ICU RCTs vs non-ICU RCTs published in the same journals
- ICU RCTsn = 132
- Outcome
- Proportion of ICU RCTs
Methodological detailssystematic literature review, 2,770 publications screened
- Systematic literature review
- 2,770 publications screened
Main finding
As reported in the abstract
ICU RCTs
5.4%
132
Further findings
Commercial funding
P < 0.001
RCTs reaching statistical significance
P < 0.001
| Outcome | ICU RCTs | Non-ICU RCTs | P value |
|---|---|---|---|
| Number of patients included | 634 | 584 | P = 0.528 |
| Fragility Index of significant RCTs | 3 | 12 | P = 0.008 |
Original publication
Randomized Controlled Trials in ICU in the Four Highest-Impact General Medicine Journals. Crit Care Med. Published 18 May 2023. doi:10.
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