ICU sedation, delirium & recovery
Reactivation of Epstein–Barr virus among intensive care patients: a prospective observational study
Authors' conclusion
While EBV reactivation was not associated with increased 90-day mortality, it was associated with significantly increased morbidity.
Study context
- Population
- Patients admitted to the intensive care unit (ICU)
- Participants
- 129 patients
- Exposure
- Epstein-Barr virus (EBV) reactivation vs no reactivation
- EBV reactivationn = 70
- Outcome
- Mortality
- Follow-up
- Day 90
Methodological detailsmulticentre, Follow-up 90 days
- Multicentre
- Follow-up 90 days
Main finding
As reported in the abstract
P = 0.22
Observational data: associations, not effects.
Further findings
Ventilator-free days · Day 28
P = 0.037
ARDS
P = 0.04
Infections
P = 0.03
Septic shock
P = 0.004
RRT required
P = 0.02
Mortality by timing of reactivation (subgroup)
- EBV reactivation at admission: increased mortality vs no reactivation and vs later reactivation
Immune profile
- EBV reactivation associated with a more inflammatory immune profile
Original publication
Reactivation of Epstein–Barr virus among intensive care patients: a prospective observational study. Intensive Care Med. Published 4 March 2024. doi:10.
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