Real-Time Ultrasound Guidance as Compared With Landmark Technique for Subclavian Central Venous Cannulation: A Systematic Review and Meta-Analysis With Trial Sequential Analysis*
Authors' conclusion
Real-time ultrasound-guided subclavian vein cannulation is safer and more efficient than a landmark approach.
Study context
- Population
- Adult patients undergoing subclavian vein cannulation6 randomized controlled trials (RCTs)
- Comparison
- Real-time ultrasound-guided vs landmark subclavian vein cannulation
- Outcome
- Overall success rate and complication rate
Methodological detailstrial sequential analysis, Sensitivity analyses added 2 static ultrasound-guided RCTs and 1 prospective study
- Trial sequential analysis
- Sensitivity analyses added 2 static ultrasound-guided RCTs and 1 prospective study
Pooled result
As reported in the abstract
Overall success rate; complication rate
Real-time ultrasound-guided vs LandmarkEstimate (95% CI)P value
I2 = 55%; low certainty
RR for overall successful cannulation 1.14(1.06–1.23)
P = 0.0007I2 = 0%; low certainty
RR for complication 0.32(0.22–0.47)
P < 0.00001Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Complication rateI2 = 0%; low certainty | 0.32 (0.22–0.47) | P < 0.00001 | |
| 0.20.5125Relative risk (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Real-Time Ultrasound Guidance as Compared With Landmark Technique for Subclavian Central Venous Cannulation: A Systematic Review and Meta-Analysis With Trial Sequential Analysis*. Crit Care Med. Published 2 March 2023. doi:10.
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