Hemodynamics, fluids & transfusion
Real-world Experience of Angiotensin II and Renin Usage in Patients With Distributive Shock:A Single-center Descriptive Study
Authors' conclusion
Angiotensin II can be used to decrease the doses of non-angiotensin II vasopressors, and renin concentration may potentially aid in the prognostication of patients with distributive shock.
Study context
- Population
- Adults with distributive shock, no limitations of active care, on norepinephrine base ≥0.3 mcg/kg/min plus vasopressin, 4 ICUs of one university hospital, August 2022–August 2023
- Outcome
- Real-life use of angiotensin II and renin
Methodological detailsobservational, single-centre, descriptive
- Observational
- Single-centre
- Descriptive
Main finding
As reported in the abstract
- Cause of distributive shock: septic shock
- 38/42, 90.5%
- Cause of distributive shock: post-cardiopulmonary bypass vasoplegia
- 4/42, 9.5%
- Norepinephrine base dose after angiotensin II initiation, 4 h (mean ± SD)
- 0.40 ± 0.25 mcg/kg/min
- Norepinephrine base dose after angiotensin II initiation, 24 h (mean ± SD)
- 0.21 ± 0.11 mcg/kg/min
- Norepinephrine base dose after angiotensin II initiation, 48 h (mean ± SD)
- 0.13 ± 0.06 mcg/kg/min
- Renin concentration decreased after angiotensin II initiation (p < 0.01)
- 376.90 ± 168.50 mU/L to 188.24 ± 167.47 mU/L
- Control renin, survivors to hospital discharge
- 78.06 ± 121.14 mU/L
- Control renin, nonsurvivors (lower in survivors, p < 0.01)
- 259.07 ± 163.4 mU/L
Observational data: associations, not effects.
Original publication
Real-world Experience of Angiotensin II and Renin Usage in Patients With Distributive Shock:A Single-center Descriptive Study. J Cardiothorac Vasc Anesth. Published 23 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →