Perioperative medicine & outcomes

Recent COVID-19 infection is associated with increased mortality in the ambulatory surgery population

J Clin AnesthPublished Retrospective cohort study

Main findingResult — go to the resultOdds ratio 2.51

Authors' conclusion

A COVID-19 positive diagnosis is associated with significantly higher risk of all-cause mortality following ambulatory surgery. This mortality risk is greatest in patients that undergo ambulatory surgery within 45 days of testing positive for COVID-19.

Study context

Population
US adults tested for COVID-19 up to 6 months before ambulatory surgery, March 2020 to March 202144,934 analysed
Participants
44,976 adults
Exposure
COVID-19 positive vs COVID-19 negative before ambulatory surgery
  • COVID-19 positiven = 4,297
  • COVID-19 negativen = 40,637reference
Outcome
All-cause mortality by testing-to-surgery interval (to Surgery Interval Mortality (TSIM)) of up to 6 months
Methodological detailsOptum dataset
  • Optum dataset

Main finding

As reported in the abstract

Odds ratio

2.51

P < 0.001

Observational data: associations, not effects.

Secondary outcomes

OutcomeORP value
Mortality by surgery type in COVID-19 positive patients (subgroup)Colonoscopy vs Other surgeries0.21P = 0.01
Mortality by surgery type in COVID-19 positive patients (subgroup)Plastic and orthopedic surgery vs Other surgeries0.27P = 0.01

All-cause mortality by testing-to-surgery interval (0-15, 16-30, 31-45, 46-180 days)

Increased mortality in COVID-19 positive patients remained high with surgery 0-45 days from testing

Original publication

Recent COVID-19 infection is associated with increased mortality in the ambulatory surgery population. J Clin Anesth. Published 8 June 2023. doi:10.1016/j.jclinane.2023.111182

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