Recurarization with magnesium sulfate administered after two minutes sugammadex reversal: A randomized, double-blind, controlled trial
Primary result · Recurarization (normalized TOFR < 0.9)Result — go to the resultRelative risk 9.0 95% CI 62–1.30Authors' conclusion
Single-dose magnesium sulfate led to a normalized train-of-four ratio < 0.9, 2 min after recovery from rocuronium-induced deep and moderate neuromuscular blockade using sugammadex. Additional sugammadex reversed prolonged recurarization.
Study context
- Population
- Patients undergoing elective otolaryngological surgery under TIVA with single-dose rocuronium (0.6 mg/kg), tertiary care hospital, Rio de Janeiro, Brazil
- Participants
- 60 patients
- Comparison
- Magnesium sulfate (60 mg/kg) vs placebo after TOF ratio recovery to ≥0.9 with sugammadex reversal
- Magnesium sulfate (deep-blockade)n = 14
- Placebo (deep-blockade)n = 14reference
- Magnesium sulfate (moderate-blockade)n = 15
- Placebo (moderate-blockade)n = 14reference
- Primary endpoint
- Number of patients with recurarization (normalized TOF ratio < 0.9)
Methodological detailssingle-centre, prospective, double-blind
- Single-centre
- Prospective
- Double-blind
Primary result
Recurarization (normalized TOFR < 0.9)
Relative risk
9.0
95% CI 62–1.30
P = 0.002
Events by treatment group
As reported in the abstract
- Absolute difference in recurarization, deep-blockade series
- 57%
- Absolute difference in recurarization, moderate-blockade series
- 73%
Secondary outcomes
Rescue with additional dose of sugammadex after 60 min
- Rescues with sugammadex, deep-blockade series
- 4
- Rescues with sugammadex, moderate-blockade series
- 2
Original publication
Recurarization with magnesium sulfate administered after two minutes sugammadex reversal: A randomized, double-blind, controlled trial. J Clin Anesth. Published 30 June 2023. doi:10.
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