Reducing rebound pain severity after arthroscopic shoulder surgery under general anesthesia and interscalene block: a two-centre randomized controlled trial of pre-emptive opioid treatment compared with placebo
Primary resultResult — go to the resultMean difference 0.6 95% CI −0.5 to 1.8Authors' conclusion
Hydromorphone 2 mg given six hours after interscalene block did not reduce the severity of rebound pain postoperatively compared with placebo in patients undergoing arthroscopic shoulder surgery.
Study context
- Population
- Patients undergoing arthroscopic shoulder surgery under GA and preoperative single-injection interscalene blockrandomised
- Participants
- 73 patients
- Comparison
- Oral hydromorphone 2 mg 6 hr after interscalene block vs placebo
- Primary endpoint
- Worst pain score (11-point 0-10 NRS)
- Follow-up
- First 24 hr postoperatively
Methodological detailstwo-centre, parallel-group, double-blind, placebo-controlled, superiority
- Two-centre
- Parallel-group
- Double-blind
- Placebo-controlled
- Superiority
Primary result
As reported in the abstract
Mean difference
0.6
95% CI −0.5 to 1.8
By group
Hydromorphone
6.5
mean · SD 2.4
Placebo
5.9
mean · SD 2.3
Hydromorphone vs Placebo
mean difference 0.6 (95% CI −0.5 to 1.8)
Further findings
Pain trajectory and opioid use
- No significant difference between the groups
Time to worst pain and to first rescue analgesia after interscalene block
- Mean time to worst pain (hr)
- 14.6
- Mean time to first rescue analgesia (hr)
- 11.3
Safety
Nausea and vomiting
- No significant difference in incidence between the groups
Original publication
Reducing rebound pain severity after arthroscopic shoulder surgery under general anesthesia and interscalene block: a two-centre randomized controlled trial of pre-emptive opioid treatment compared with placebo. Can J Anaesth. Published 13 October 2023. doi:10.
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