Regional analgesia catheter-related infections and the effectiveness of antibiotic prophylaxis in immunocompromised patients: A retrospective multicenter registry analysis
Authors' conclusion
Regional analgesia catheter-related infections occur slightly earlier and are more frequent in immunocompromised patients. Antibiotics are marginally effective for catheter infection prophylaxis
Study context
- Population
- Patients with regional analgesia catheters in the net-ra registry, 2007–2022
- Participants
- 196,711 catheters
- Exposure
- Immunocompromised vs immunocompetent; antibiotic prophylaxis vs none
- Immunocompromisedn = 1,347
- Outcome
- Catheter-related infection onset and severity
Methodological detailsregistry (net-ra, 2007–2022), multivariable cox and ordinal regression
- Registry (net-ra, 2007–2022)
- Multivariable cox and ordinal regression
Main finding
As reported in the abstract
Infection severity
Immunocompromised without antibioticsEstimate (95 % CI)P value
Infection hazard
HR 1.29(0.95–1.76)
P = 0.1Odds of higher infection severity
OR 1.91(1.39–2.63)
P < 0.001Observational data: associations, not effects.
Further findings
NNT
| Outcome | Immunocompromised | Immunocompetent | Estimate | P value | |
|---|---|---|---|---|---|
| Antibiotic effectiveness, immunocompromised vs immunocompetentDelaying infection onset | 55 | 83 | HR 0.65 (95 % CI 0.38–1.12) | P = 0.12 | |
| Antibiotic effectiveness, immunocompromised vs immunocompetentPreventing infection | OR 0.54 (95 % CI 0.31–0.94) | P = 0.029 | |||
| 0.20.5125Ratio (log scale) |
Original publication
Regional analgesia catheter-related infections and the effectiveness of antibiotic prophylaxis in immunocompromised patients: A retrospective multicenter registry analysis. J Clin Anesth. Published 4 April 2025. doi:10.
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