Neuroanesthesia & neurocritical care
Relationship Between Systemic and Cerebral Microdialysate Glucose in Patients With Severe Acute Brain Injury—A Retrospective Study
Authors' conclusion
In this retrospective analysis of patients with severe acute brain injury undergoing intracerebral microdialysis, changes in systemic glucose contributed to changes in CMD-glucose with no relation to functional outcome.
Study context
- Population
- Patients with severe acute brain injury (severe traumatic brain injury (TBI) or aneurysmal subarachnoid haemorrhage (SAH)) undergoing cerebral microdialysis
- Participants
- 133 patients
- Exposure
- SAH vs TBI
- SAHn = 75
- TBIn = 58
- Outcome
- Relationship between systemic glucose and microdialysate glucose (CMD-glucose)
Main finding
As reported in the abstract
CMD-glucose variation explained by systemic glucose (R2)
Observational data: associations, not effects.
Further findings
Increase in CMD-glucose per 1 mmol/L increase in systemic glucose (linear regression)
Time from ictus
- Both systemic and CMD-glucose decreased with increasing time from ictus
Disease severity (admission GCS) and functional outcome (modified Rankin Scale) · 6 months
- No association between CMD-glucose and disease severity or functional outcome
Original publication
Relationship Between Systemic and Cerebral Microdialysate Glucose in Patients With Severe Acute Brain Injury—A Retrospective Study. Acta Anaesthesiol Scand. Published 17 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →