Neuroanesthesia & neurocritical care
Effect of controlled blood pressure increase on cerebral blood flow velocity and oxygenation in patients with subarachnoid haemorrhage
Authors' conclusion
In this study of patients with SAH, MCAv was not significantly affected by a brief course of controlled blood pressure increase; despite this, PbtO2 increased.
Study context
- Population
- Patients with aneurysmal subarachnoid haemorrhage (SAH) within 5 days after ictus, before any signs of delayed cerebral ischaemia
- Participants
- 36 patients
- Comparison
- Controlled BP increase vs baseline
- Outcome
- Difference in middle cerebral artery blood flow velocity (MCAv) measured by transcranial Doppler
- Follow-up
- After 20 min of noradrenaline infusion
Methodological detailsbefore-after (baseline vs controlled BP increase), Intervention 4 (median, IQR: 3-4.75) days after ictus
- Before-after (baseline vs controlled BP increase)
- Intervention 4 (median, IQR: 3-4.75) days after ictus
Main finding
As reported in the abstract
MCAv
P-value: .054
Further findings
Brain tissue oxygen tension (PbtO2) (exploratory) · increased significantly
P < 0.001
MAP (achieved with noradrenaline) · after 20 min of noradrenaline infusion
- MAP increased from 82 (IQR: 76-85) to 95 (IQR: 88-98) mmHg
- p-value: <.001
Intracranial pressure (ICP) and microdialysis markers of cerebral oxidative metabolism and cell injury (exploratory)
- The remaining exploratory outcomes were unchanged
Original publication
Effect of controlled blood pressure increase on cerebral blood flow velocity and oxygenation in patients with subarachnoid haemorrhage. Acta Anaesthesiol Scand. Published 16 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →