Relationships between common carotid artery blood flow and anesthesia, pneumoperitoneum, and head-down tilt position: a linear mixed-effect analysis
Authors' conclusion
CCA blood flow was significantly decreased by anesthesia induction. Inducing pneumoperitoneum, with or without the head-down tilt position, did not further decrease CCA blood flow if the cardiac index remained unchanged. The cardiac index and stroke volume index were significantly associated with CCA blood flow.
Study context
- Population
- Patients undergoing gynecological surgery
- Participants
- 20 patients
- Exposure
- Common carotid artery (CCA) blood flow across 4 time points: awake supine, after anaesthesia induction, after pneumoperitoneum supine, after pneumoperitoneum head-down tilt
- Outcome
- Common carotid artery (CCA) blood flow measured by Doppler ultrasound
Methodological detailslinear mixed-effect analysis, repeated measures
- Linear mixed-effect analysis
- Repeated measures
Main finding
As reported in the abstract
CCA blood flow
T1
345.4
range 288.0–392.9
T2
293.1
range 253.0–342.6
T3
283.6
range 258.8–307.6
T4
287.1
range 242.1–321.4
T2 vs T1: P = 0.048 · T3 vs T1: P = 0.005 · T4 vs T1: P = 0.016
Observational data: associations, not effects.
Further findings
Association of changes in CCA blood flow with haemodynamic parameters
- Significantly associated with changes in cardiac index (P)
- P = 0.011
- Significantly associated with changes in stroke volume index (P)
- 0.024
Original publication
Relationships between common carotid artery blood flow and anesthesia, pneumoperitoneum, and head-down tilt position: a linear mixed-effect analysis. J Clin Monit Comput. Published 4 December 2022. doi:10.
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