Relative faecal abundance to predict extended-spectrum β-lactamase-producing Enterobacterales related ventilator‑associated pneumonia
Authors' conclusion
RAC was not associated with confirmed VAP in ESBL-E carriers.
Study context
- Population
- ESBL-E carriers with confirmed ventilator-associated pneumonia (VAP), medical ICU of a university hospital, October 2019–April 2023131 VAP episodes in 83 patients
- Participants
- 478 carriers
- Outcome
- Predictive value of relative abundance of ESBL-E rectal carriage (RAC) for ESBL-E-related VAP
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Association of RAC with ESBL-E-related VAP
- Rectal carriage (RAC) not associated with ESBL-E-related VAP in the entire cohort
- p = 0.39
- ESBL-E-related VAP episodes
- 62 episodes (47%)
Observational data: associations, not effects.
Further findings
Rectal colonization with non-Escherichia coli ESBL strains and ESBL-E-related VAP (multivariable model)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Non-Escherichia coli ESBL colonization | 1.213 (1.005–1.463) | P = 0.045 | |
| 0.512Adjusted odds ratio (log scale) |
Sensitivity analyses: association of RAC with ESBL-E-related VAP (subsets)
- Recent, high-quality screening (≤ 7 days, > 104 CFU/mL)
- P = 0.21
- First VAP episodes only
- P = 0.41
- Escherichia coli exclusively
- P = 0.08
- Other ESBL-E strains
- P = 0.29
- VAP with Gram-negative bacteria
- P = 0.26
- VAP with Enterobacterales
- P = 0.34
Original publication
Relative faecal abundance to predict extended-spectrum β-lactamase-producing Enterobacterales related ventilator‑associated pneumonia. Ann Intensive Care. Published 20 March 2025. doi:10.
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