Remifentanil for tracheal intubation without neuromuscular blocking drugs in adult patients: a systematic review and meta‐analysis
Pooled result · Tracheal intubation success rateResult — go to the resultRR for successful intubation 0.97 95% CI 0.94–1.01Authors' conclusion
We conclude that remifentanil may be used as an alternative drug for tracheal intubation in cases where neuromuscular blocking drugs are best avoided
Study context
- Population
- Adults undergoing tracheal intubation
- Participants
- 1,945 adults · 21 studies
- Comparison
- Remifentanil vs NMBA for tracheal intubation
- Outcome
- Tracheal intubation conditions and adverse events
Pooled result
Tracheal intubation success rate
RR for successful intubation
0.97
95% CI 0.94–1.01
P = 0.16
Remifentanil vs Neuromuscular blocking drugs
RR for successful intubation 0.97 (95% CI 0.94–1.01); P = 0.16
As reported in the abstract
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Excellent tracheal intubation conditions (remifentanil 2.0-4.0 μg.kg-1)Remifentanil vs NMBA | 1.16 (0.72–1.87) | P = 0.54 | |
| 0.512Relative risk (log scale) |
- Excellent tracheal intubation conditions (remifentanil 2.0-4.0 μg.kg-1): two studies; 121 participants; I2 31%; moderate-certainty of evidence
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Bradycardia (remifentanil 2.0-4.0 μg.kg-1)Remifentanil vs NMBA · two studies; 997 participants; I2 81% · very low-certainty evidence | 0.44 (0.01–13.90) | P = 0.64 | |
| Hypotension (remifentanil 2.0-4.0 μg.kg-1)Remifentanil vs NMBA · three studies; 1071 participants; I2 92% · very low-certainty evidence | 1.05 (0.44–2.49) | P = 0.92 | |
| 0.050.21520Relative risk (log scale) |
Original publication
Remifentanil for tracheal intubation without neuromuscular blocking drugs in adult patients: a systematic review and meta‐analysis. Anaesthesia. Published 25 February 2024. doi:10.
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