Renal Adverse Events Associated With Ibuprofen Treatment After Hip and Knee Arthroplasties— A Protocol for the Preplanned Substudy of the PERISAFE Trial
Study context
- Population
- Patients undergoing hip or knee arthroplastyplanned
- Participants
- 2,904 patients
- Planned comparison
- Ibuprofen vs Placebo
- Primary endpoint
- Number of patients with renal dysfunction according to RIFLE criteria Level 1-5
- Follow-up
- any point during the 90-day follow-up
Methodological detailsplacebo-controlled, blinded, multicentre, Powered at 86.3% to detect or discard a 40% relative risk reduction, assuming an incidence of acute renal injury of 6.2%
- Placebo-controlled
- Blinded
- Multicentre
- Powered at 86.3% to detect or discard a 40% relative risk reduction, assuming an incidence of acute renal injury of 6.2%
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Renal Adverse Events Associated With Ibuprofen Treatment After Hip and Knee Arthroplasties— A Protocol for the Preplanned Substudy of the PERISAFE Trial. Acta Anaesthesiol Scand. Published 12 March 2026. doi:10.
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