Minimal important difference in postoperative morphine consumption after hip and knee arthroplasty using nausea, vomiting, sedation and dizziness as anchors
Primary result · Difference in iv morphine consumption, no vs only mild eventsResult — go to the resultHodges-Lehmann median difference 6 mg 95% CI 4–8Authors' conclusion
In populations comparable to this post-hoc analysis (orthopaedic surgery, median age 70 and ASA 2), we suggest a minimally important difference of 5 mg for 0-24 h postoperative iv morphine consumption.
Study context
- Population
- Patients after hip or knee arthroplasty (PANSAID, DEX-2-TKA and Pain Map studies); median age 70, median ASA 2, 54% female3 studies
- Comparison
- 0–24 h postoperative iv morphine equivalent consumption by severity of opioid-related adverse events (nausea, vomiting, sedation, dizziness)
- Primary endpoint
- Difference in morphine consumption between patients with no vs only mild events
- Follow-up
- 0–24 h postoperative
Methodological detailsanchor-based methods
- Anchor-based methods
Primary result
As reported in the abstract
Difference in iv morphine consumption, no vs only mild events · 0–24 h
Hodges-Lehmann median difference
6 mg
95% CI 4–8
Mild vs No events
Hodges-Lehmann median difference 6 mg (95% CI 4–8)
Secondary outcomes
| Outcome | Hodges-Lehmann median difference (mg) (CI) | |
|---|---|---|
| Difference in iv morphine consumption, mild vs moderate events · 0–24 h | 5 (2–8) | |
| Difference in iv morphine consumption, moderate vs severe events · 0–24 h | 0 (−4 to 4) | |
| −50510Difference, mg (linear scale) |
Original publication
Minimal important difference in postoperative morphine consumption after hip and knee arthroplasty using nausea, vomiting, sedation and dizziness as anchors. Acta Anaesthesiol Scand. Published 21 February 2024. doi:10.
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