Pain medicine

Minimal important difference in opioid consumption based on adverse event reduction—A study protocol

Acta Anaesthesiol ScandPublished Study protocol for a post-hoc analysis of aggregated data from two clinical trials and one observational cohort study

Study context

Population
Patients undergoing total hip and knee arthroplasty (PANSAID, DEX2TKA, Pain Map)
Planned comparison
Opioid consumption in patients with no vs mildest degree of opioid-related adverse effects
Primary endpoint
Hodges-Lehmann median difference in opioid consumption between patients with no opioid-related adverse effects and those with the mildest degree of ≥1 opioid-related adverse effect

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Minimal important difference in opioid consumption based on adverse event reduction—A study protocol. Acta Anaesthesiol Scand. Published 9 December 2022. doi:10.1111/aas.14175

Composed by AI from the published abstract and checked against it. How Briefs are made →

Get them every week

New studies on this topic in My Week and in your Monday e-mail.

We e-mail you a sign-in link and a code. No password, no spam.