Repeat Versus Single Quadratus Lumborum Block to Reduce Opioids After Open Pancreatectomy (RESQU-BLOCK)): A Randomized Clinical Trial
Authors' conclusion
Addition of a second, "rescue" block to an opioid reduction bundle did not significantly improve opioid-free discharges after open pancreatectomy and was not required to discharge >1/3 of patients opioid-free.
Study context
- Population
- Patients undergoing open pancreatectomy104 completed
- Participants
- 106 patients
- Comparison
- Standardized analgesic bundle with vs without a second QL block on POD4
- Second-blockn = 52
- Single-blockn = 52reference
- Primary endpoint
- Proportion of opioid-free discharges
Methodological detailssingle-institution, unblinded, phase II, post hoc Bayesian analyses
- Single-institution
- Unblinded
- Phase II
- Post hoc Bayesian analyses
Primary result
As reported in the abstract
Secondary outcomes
Discharge prescription OME
Patient-reported pain and life interference scores · discharge and 1 month
- Improved (lower) scores in the second-block arm
Original publication
Repeat Versus Single Quadratus Lumborum Block to Reduce Opioids After Open Pancreatectomy (RESQU-BLOCK)): A Randomized Clinical Trial. Ann Surg. Published 27 May 2025. doi:10.
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