Comparison of three different methods of postoperative analgesic effects in laparoscopic major liver resection (systemic analgesia vs. erector spinae plane block vs. quadratus lumborum block): A randomized controlled trial
Authors' conclusion
Neither ESPB nor posterior QLB resulted in a significant decrease in cumulative opioid consumption within 24 h after laparoscopic major liver resection.
Study context
- Population
- Patients undergoing laparoscopic major liver resection
- Participants
- 114 patients
- Comparison
- Single-shot ESP block or posterior QL block (40 mL 0.5% ropivacaine) plus systemic analgesia vs systemic analgesia alone
- Primary endpoint
- Cumulative opioid consumption
- Follow-up
- 24 h post-surgery
Methodological detailssingle-centre, three-arm (1:1:1), August 2022 to January 2024
- Single-centre
- Three-arm (1:1:1)
- August 2022 to January 2024
Primary result
As reported in the abstract
adjP > 0.99
Secondary outcomes
Cumulative opioid consumption at 1 and 48 h
- No significant difference among the three groups at 1 h
- adjP = 0.336
- No significant difference among the three groups at 48 h
- 0.732
Cumulative opioid consumption at 72 h · 72 h post-surgery
- Significantly lower at 72 h
- adjP = 0.032
Pain at rest and when coughing
- Pain at rest lower in erector spinae plane block (ESPB) and quadratus lumborum block (QLB) vs control during postanesthesia care unit (PACU) stay and at 48 h
- Pain when coughing reduced in both block groups only during PACU stay
Original publication
Comparison of three different methods of postoperative analgesic effects in laparoscopic major liver resection (systemic analgesia vs. erector spinae plane block vs. quadratus lumborum block): A randomized controlled trial. J Clin Anesth. Published 14 October 2025. doi:10.
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