Systemic lidocaine versus erector spinae plane block for improving quality of recovery after laparoscopic cholecystectomy: A randomized controlled trial
Authors' conclusion
For patients undergoing laparoscopic cholecystectomy, intravenous lidocaine provides a non-inferior quality of recovery compared to ESPB without requiring specialized regional anesthesia procedures.
Study context
- Population
- Adults aged 18–65 years undergoing elective laparoscopic cholecystectomy124 completed
- Participants
- 126 adults
- Comparison
- IV lidocaine vs ESP block vs placebo
- Primary endpoint
- QoR-15 score
- Follow-up
- 24-h postoperative
Methodological detailsprospective, triple-arm, double-blind, placebo-controlled, non-inferiority, single-centre
- Prospective
- Triple-arm
- Double-blind
- Placebo-controlled
- Non-inferiority
- Single-centre
Primary result
As reported in the abstract
24 h
Lidocaine
123
median · IQR 117–127
Erector spinae plane block (ESPB)
124
median · IQR 119–126
Placebo
112
median · IQR 108–117
Median differenceP value
Lidocaine vs ESPBnon-inferior; margin −6 points
−1(97.5% CI −4 to ∞)
Lidocaine vs Placebo
9(95% CI 6–12)
P < 0.001ESPB vs Placebo
10(95% CI 7–13)
P < 0.001Secondary outcomes
24-h AUC for pain scores and morphine use
- Lower with lidocaine and ESPB vs placebo
- P < 0.001 for all
- No significant differences between lidocaine and ESPB
Safety
- Block-related complications — ESPB
- 1 events
Block-related complications
- One ESPB patient reported transient metallic taste; no other block-related complications
Original publication
Systemic lidocaine versus erector spinae plane block for improving quality of recovery after laparoscopic cholecystectomy: A randomized controlled trial. J Clin Anesth. Published 20 June 2024. doi:10.
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