Respiratory failure & ventilation
Respiratory effects of pressure support ventilation in spontaneously breathing patients under anaesthesia: Randomised controlled trial
Authors' conclusion
These results suggest that pressure support ventilation protects against postoperative lung-volume loss without affecting ventilation inhomogeneity in spontaneously breathing patients with increased risk for atelectasis development.
Study context
- Population
- Adult female patients scheduled for elective gynaecological surgery in lithotomy position, breathing spontaneously through LMAMBW completed in 18 per group
- Participants
- 20 vs 20
- Comparison
- Pressure support ventilation vs continuous spontaneous breathing via LMA
- CSBn = 20reference
- PSVn = 20
- Primary endpoint
- Lung clearance index (multiple-breath nitrogen washout), relative change
- Follow-up
- 1 h postoperatively
Methodological detailsblinded outcome assessment, single-centre, Lung function measured before anaesthesia and 1 h postoperatively by a researcher blinded to allocation
- Blinded outcome assessment
- Single-centre
- Lung function measured before anaesthesia and 1 h postoperatively by a researcher blinded to allocation
Primary result
As reported in the abstract
Relative change in lung clearance index
CSB
−0.035
± 7.1 · %
PSV
−0.18
± 6.6 · %
P = 0.963
Further findings
Decrease in end-expiratory lung volume · 1 h postoperatively · more pronounced decrease in CSB
P = 0.0259
Postoperative changes in small airway function and respiratory tissue stiffness (forced oscillations) · 1 h postoperatively
- Significantly lower in PSV than CSB (p < .05 for both)
Original publication
Respiratory effects of pressure support ventilation in spontaneously breathing patients under anaesthesia: Randomised controlled trial. Acta Anaesthesiol Scand. Published 3 November 2023. doi:10.
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