Response to furosemide and the receipt of kidney replacement therapy in critically ill patients
Authors' conclusion
This study demonstrates that the response to a first furosemide bolus administered during usual clinical care can be a valuable tool for anticipating the future receipt of KRT.
Study context
- Population
- Critically ill adults in a tertiary care hospital ICU, 2017–2023, receiving a first IV furosemide bolus with documented urine output (continuous furosemide infusion excluded)included in the analysis
- Participants
- 1,527 adults
- Exposure
- ≤25 mL/h vs >50 mL/h
- Outcome
- Initiation of KRT
- Follow-up
- Within 7 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
KRT within 7 days by 2-h urine output
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95 % CI) | |
|---|---|---|
| KRT initiation by 6-h urine output (multivariable analysis)Per 10 mL/h increase | 0.905 (0.861–0.951) | |
| 0.512Adjusted odds ratio (log scale) |
Kidney replacement therapy (KRT) by 6-h urine output
- Similar patterns observed for urine output at 6 h
Acute kidney injury (AKI) progression and KDIGO stage
- Lower urine output associated with greater AKI progression and higher KDIGO stages
Original publication
Response to furosemide and the receipt of kidney replacement therapy in critically ill patients. J Crit Care. Published 5 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →