ICU sedation, delirium & recovery
Responsiveness of Critically Ill Adults With Multimorbidity to Rehabilitation Interventions: A Patient-Level Meta-Analysis Using Individual Pooled Data From Four Randomized Trials*
Authors' conclusion
The identification of a target group with two or more comorbidities who derived benefits from the trial interventions is an important finding and provides direction for future investigations into the effect of rehabilitation.
Study context
- Population
- Critically ill adults in critical care physical rehabilitation randomized controlled trials (RCTs)
- Participants
- 810 adults · 4 RCTs
- Comparison
- Physical rehabilitation vs control
- Interventionn = 403
- Controln = 407reference
- Outcome
- Coprimary: HRQoL and objective physical performance, and their modification by patient characteristics (pre-existing comorbidity, age, sex, illness severity)
Methodological detailslinear mixed models, effect modification analysis
- Linear mixed models
- Effect modification analysis
Pooled result
As reported in the abstract
Effect modification of HRQoL and physical performance by patient characteristics (subgroups) · 3 and 6 months
≥2 comorbidities: Health-related quality of life (HRQoL) (Physical Component Summary) significantly higher with intervention vs similarly comorbid control, exceeding the minimal important difference
Wald test p = 0.041
Original publication
Responsiveness of Critically Ill Adults With Multimorbidity to Rehabilitation Interventions: A Patient-Level Meta-Analysis Using Individual Pooled Data From Four Randomized Trials*. Crit Care Med. Published 30 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →