Cardiac arrest & resuscitation
Resuscitation Attempt and Outcomes in Patients With Asystole Out-of-Hospital Cardiac Arrest
Authors' conclusion
In this cohort study of patients with OHCA presenting with asystole, the proportion with a favorable neurological outcome at 30 days was substantially low, and no prehospital ALS procedure was associated with a favorable neurological outcome.
Study context
- Population
- Adults with out-of-hospital cardiac arrest (OHCA) and initial rhythm of asystole, Japan, June 2014–December 2020asystole among 60,349 OHCA
- Participants
- 35,843 adults
- Exposure
- Prehospital advanced life support (ALS) procedures vs none; trends by year of OHCA
- Outcome
- Favorable neurological outcome
- Follow-up
- 30 days
Methodological detailsnationwide prospective OHCA registry, time-dependent propensity score and risk-set matching
- Nationwide prospective OHCA registry
- Time-dependent propensity score and risk-set matching
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
AAM
1.27(0.76–2.12)
P = 0.36Intravenous epinephrine
0.53(0.24–1.13)
P = 0.10- Favorable neurological outcome at 30 days among 33 674 with ALS procedures
- 67 (0.2%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR for survival (95% CI) | P value | |
|---|---|---|---|
| Survival at 30 daysAAM vs No AAM · time-dependent propensity score and risk-set matching | 1.45 (1.21–1.74) | P < 0.001 | |
| 0.512OR for survival (log scale) |
ROSC trend over study period
- Decline in ROSC
- 424 of 1848 [22.9%] to 1178 of 5892 [20.0%]; P = .003
Trends in other outcomes
- No significant trends in the outcomes except ROSC
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Resuscitation Attempt and Outcomes in Patients With Asystole Out-of-Hospital Cardiac Arrest. JAMA Netw Open. Published 4 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →